三、主要科研工作与成绩 近5年主持的科研课题 2022年国家自然科学基金面上项目：“过氧化物酶6线粒体转位调控铁死亡在急性肺损伤中的作用及机制研究”（项目编号：82170091，第一申请人；经费54万元；2022年1月-2025年12月） 2020年复旦大学附属中山医院智慧医疗项目：“基于慢性气道病专病队列和多组学分析揭示小气道病变和慢阻肺急性加重低嗜酸粒细胞表型的特征”（经费：10万元；2020年11月-2023年11月） 2020年国家自然科学基金面上项目：“硒过氧化物酶6在胞外介导上皮细胞炎症损伤的二次打击加重ALI的作用及机制”（项目编号：81970069，第一申请人；经费55万元；2020年1月-2023年12月） 2018年徐汇区科普创新项目：“线下与线上结合模式在慢阻肺肺癌患者术后科普活动中的应用”（第一申请人；经费：5万元；2018年7月至2019年6月） 2017年科技部重点专项“慢性阻塞性肺疾病急性加重预警与预防策略研究”（项目编号：2017YFC1310600）的子课题：慢阻肺急性加重的免疫组学研究（项目编号：2017YFC1310602，第一申请人；经费：100万元；2017年7月-2020年12月） 2016年上海市卫计委科研基金：“Peroxiredoxin6调控ALI修复期肺间质纤维化的ROS-自噬-上皮间质转化机制”（项目编号：201540078，第一申请人；经费5万元；2016年1月-2018年12月）
近5年以第一作者或通讯作者发表文章 Wei T, Wang X,Lang K, Chen C, Song Y, Luo J, Gu Z, Hu X, YangD（通讯）.Low Eosinophil Phenotype Predicts Noninvasive MechanicalVentilation Use in Patients with Hospitalized Exacerbations ofCOPD. J Inflamm Res. 2022 Feb 24;15: 1259-1271. Zhong P, Xu J,Yang D（共一）,Shen Y, Wang L, Feng Y, Du C, Song Y, Wu C, Hu X, Sun Y.COVID-19-associated gastrointestinal and liver injury: clinicalfeatures and potential mechanisms. Signal Transduct Target Ther.2020 Nov 2;5(1):256. Liu J, Chen X,Zhou J, Ye L, Yang D（共通）,Song Y. Particulate matter exposure promotes Pseudomonasaeruginosa invasion into airway epithelia by upregulating PAFRvia the ROS-mediated PI3K pathway. Hum Cell. 2020Oct;33(4):963-973. Wu C, Hu X,Song J, Yang D（共一）,Xu J, Cheng K, Chen D, Zhong M, Jiang J, Xiong W, Lang K, Tao Y,Lin X, Shi G, Lu L, Pan L, Xu L, Zhou X, Song Y, Wei M, Zheng J,Du C. Mental health status and related influencing factors ofCOVID-19 survivors in Wuhan, China. Clin Transl Med. 2020Jun;10(2): e52. Xiang-Lin Hu,Song-Tao Xu, Xiao-Cen Wang, Jin-Long Luo, Dong-Ni Hou, Xiao-MinZhang, Chen Bao, Dong Yang（通讯）,Yuan-Lin Song, Chun-Xue Bai. Development and validation ofnomogram estimating post-surgery hospital stay of lung cancerpatients: relevance for predictive, preventive, and personalizedhealthcare strategies. EPMA J. 2019, 10 (2), 173-183. Xiaocen Wang,Xiaojing An, Xun Wang, Xianglin Hu, Jing Bi, Ling Tong, Dong Yang（通讯）,Yuanlin Song, Chunxue Bai. Peroxiredoxin 6 Knockout AggravatesCecal Ligation and Puncture-Induced Acute Lung Injury.International Immunopharmacology. 2019, 68(3), 252-258. Xiang-Lin Hu,Song-Tao Xu, Xiao-Cen Wang, Dong-Ni Hou, Cui-Cui Chen, Dong Yang（通讯）,Yuan-Lin Song. Lung cancer patients with a previousextra-pulmonary malignancy should not be considered homogeneous:a clinicopathological analysis of 3,530 surgical cases. Clinicaland Translational Oncology. 2019,21(3):348-354. Nan Wu, DongYang （共一）,Zhenchao Wu, Mengdie Yan, Pengju Zhang, Yi Liu. Insulin in highconcentration recede cigarette smoke extract induced cellularsenescence of airway epithelial cell through autophagy pathway.Biochemical and Biophysical Research Communications.2019,509(2), 498-505 Xun Wang,Xiaojing An, Xiaocen Wang, Chen Bao, Jing Li, DongYang（通讯）,Chunxue Bai. Curcumin ameliorated ventilator-induced lung injuryin rats. Biomedicine & Pharmacotherapy. 2018,98(2):754–761. Xiang-Lin Hu,Song-Tao Xu, Xiao-Cen Wang, Dong-Ni Hou, Cui-Cui Chen, Yuan-LinSong, Dong Yang（通讯）.Prevalence of and risk factors for presenting initialrespiratory symptoms in patients undergoing surgery for lungcancer. Journal of Cancer. 2018,31;9(19):3515-3521 Xiang-Lin Hu,Song-Tao Xu, Xiao-Cen Wang, Dong-Ni Hou, Cui-Cui Chen, DongYang（通讯）,Yuan-Lin Song. Status of coexisting chronic obstructivepulmonary disease and its clinicopathological features inpatients undergoing lung cancer surgery: a cross-sectional studyof 3,006 cases. Journal of Thoracic Disease.2018,10(4):2403-2411. Zhenchao Wu,Dong Yang（共一）,Zhengwei Ge, Mengdie Yan, Nan Wu, Yi Liu. Body Mass Index ofPatients with Chronic Obstructive Pulmonary Disease IsAssociated with Pulmonary Function and Exacerbations: ARetrospective Real World Research. Journal of Thoracic Disease.2018 10(8):5086-5099 Jiangtao Lin,Ying Nong, Dong Yang（共通）,Shiyue Li, Guangfa Wang, Nan Su, Nanshan Zhong. Chineseconsensus statement on standard procedure and perioperativemanagement of bronchial thermoplasty. Journal of ThoracicDisease. 2017,9(12):5507-5514. Chen Bao,Xiaocen Wang, Yuan Ji, Chen Xu, DongYang（共通）,Chunxue Bai. Clinical and pathological characteristics ofpulmonary mucosa-associated lymphoid tissue lymphoma: a casereport. International Journal of Clinical Experimental Medicine.2017,10(4):7231-7235 DongYang（第一）,Meiling Jin, Chunxue Bai, Jian Zhou, Yao Shen. Peroxiredoxin 6suppresses Muc5ac overproduction in LPS-induced airwayinflammation through H2O2-EGFR-MAPKsignaling pathway. Respiratory Physiology & Neurobiology.2017,236(2):84-90. DongYang（第一）,Xixin Yan, Jian Zhou, Bei He, Chunhua Chi, Kunling Shen,Baiqiang Cai, Chunxue Bai. Chinese experts consensus for aerosoltherapy assisted by Internet of Things. Clinical eHealth. 2018,July. Accepted. https://doi.org/10.1016/j.ceh.2018.07.001 包晨，王晓岑，胡湘麟，侯东妮，陈翠翠，宋元林，杨冬(通信作者).肺原发性黏膜相关淋巴组织淋巴瘤临床特征分析.中华医学杂志,2018, 98(18): 1419-1423. 杨冬(通信作者)，侯东妮.重症哮喘的流行病学和疾病负担.中华结核和呼吸杂志,2017, 40(11): 808-809.
专利 实用新型专利：“基于手机云加端物联网的FeNO监测和分析管理系统”（ZL2013 2 0523621.9；2013年08月26日） |
