三、主要科研工作与成绩 科研项目、论文、专著专利等 科研项目： 项目下达编号项目、课题名称项目来源项目起讫时间资助经费（万元）负责人 32170805皮肤源性神经干细胞介导肠动力的潜能和机制研究国家自然科学基金委2022.01-2025.1258陈伟 23ZR1427300含有光通道的多能干细胞对肠动力障碍模型的动力介导及机制研究上海市科学技术委员会2023.04-2026.0320万元陈伟 横向经费新型重导T细胞双抗对乳腺癌治疗作用的小鼠实验评价横向课题2023.03-2023.0815万元陈伟 横向经费功能因子对肠上皮屏障和小鼠肠炎保护作用的实验评价横向课题2025.03-2027.0320万元陈伟 横向经费源于人皮肤的间充质干细胞的获取和培养体系的优化横向课题2019.07-2021.12100 陈伟 2020C03113临床级神经干细胞制备关键技术研究及应用标准化开发省级重点研发计划子项目2019.07-2022.650 陈伟人 LZ18C090001神经干细胞移植治疗巨结肠动物模型的结构和功能研究 浙江省自然科学基金重点2018.1-2021.1240 陈伟 自体牙齿干细胞存储技术服务及间充质干细胞公共库的建设厦门市第十批“双百计划”人才目2018.1-2021.12200万（到企业）陈伟 2014CB541700单基因遗传性聋病的分子机制研究国家科学技术部子项目2014.1-2018.12120 陈伟 2012CB967903干细胞内耳植入及功能验证国家科学技术部子项目2012.6-2016.12120 陈伟 31171423人体内耳毛细胞从胚胎干细胞的高纯度分化以及Cdx2的可能促进作用国家自然科学基金委2012.1-2015.1260 陈伟 论文： 1. Du Q, Li J, Li G, Wang Z, Yu S, Wang L, Guo X, Wang D, Hui B, TuY, Sun W, Zhang X*,Chen W*.Lutonarin Attenuates LPS-Induced Intestinal Epithelial BarrierDysfunction: A Functional and Transcriptomic Analysis. ActaBiochimica et Biophysica Sinica, In Press. [2] Building an Application-Oriented Pharmaceutical LaboratorySafety and Ethics Education System Based on EHs Principles:Challenges and strategies. Bin Hui, Liyou Cui, Ruifeng Guo, MeiZhao, Yanjuan Huang & Wei Chen. Journal of AcademicEthics 2025. DOI: 10.1007/s10805-025-09609-z. [3] Chen Y, Mu W, Wu Y, Xu J, Li X, Hu H, Wang S, Wang D, Hui B, WangL, Dong Y, Chen W.Optogenetically modified human embryonic stem cell-derived oticneurons establish functional synaptic connection with cochlearnuclei. Journal of Tissue engineering.(https://DOI: 10.1177/20417314241265198).(中科院1区，最后通讯) [4]LiY, Lv S, Yuan H, Ye G, Mu W, Fu Y, Zhang X, Feng Z, He Y, ChenW. Peripheral Nerve Regeneration with 3DPrinted Bionic Scaffolds Loading Neural Crest Stem Cell DerivedSchwann Cell Progenitors. AdvancedFunctional Materials;n/a(n/a):2010215.ArticleDOI:10.1002/adfm.202010215, Publishedonline.（IF=19.924,通讯作者，引用次数55次） [5]YuanH, Hu H, Chen R, Mu W, Wang L, Li Y, Chen Y, Ding X, Xi Y, Mao S,Jiang M, Chen J, He Y, Wang L, Dong Y, Tou J, ChenW. Premigratory neural crest stem cellsgenerate enteric neurons populating the mouse colon and regulatingperistalsis in tissue-engineered intestine. StemCells Translational Medicine 2021. ArticleDOI: 10.1002/sctm.20-0469, Published online. （IF=7.655,封面文章，通讯作者，引用次数15） [6]YuQ, Du M, Zhang W, Liu L, Gao Z, Chen W,Gu Y, Zhu K, Niu X, Sun Q, Wang L. Mesenteric Neural Crest CellsAre the Embryological Basis of Skip Segment Hirschsprung'sDisease. Cell Mol Gastroenterol Hepatol2020. Article DOI:10.1016/j.jcmgh.2020.12.010. (IF=8.797) [7]XuJ, Wang Y, He J, Xia W, Zou Y, Ruan W, Lou Q, Li Y, Li H, ChenW. Generation of a humanCharcot-Marie-Tooth disease type 1B (CMT1B) iPSC line,ZJUCHi001-A, with a mutation of c.292C>T in MPZ. StemCell Research 2019;35:101407. （IF=1.587,通讯作者） [8]XieC, Gao Q, Wang P, Shao L, Yuan H, Fu J, ChenW, He Y. Structure-induced cell growth by3D printing of heterogeneous scaffolds with ultrafine fibers.Materials & Design2019;181:108092. (IF=9.417) [9]XuJ, Fu Y, Xia W, He J, Zou Y, Ruan W, Lou Q, Li Y, Pan J, Li H,Chen W. Generation of induced pluripotentstem cell line, ZJUCHi002-A, from Charcot-Marie-Tooth disease type2A (CMT2A) patient with a mutation of c.752C>T in MFN2. StemCell Research 2019;36:101411.（IF=1.587,通讯作者，引用次数2） [10]NieJ, Gao Q, Wang YD, Zeng JH, Zhao HM, Sun Y, Shen J, Ramezani H, FuZL, Liu ZJ, Xiang MX, Fu JZ, Zhao P, ChenW, He Y. Vessel-on-a-chip withHydrogel-based Microfluidics. Small2018;14(45). （IF=15.153,Q1，共同通讯作者，引用次数174） [11]HuH, Ding Y, Mu W, Li Y, Wang Y, Jiang W, Fu Y, Tou J, ChenW. DRG-Derived Neural ProgenitorsDifferentiate into Functional Enteric Neurons FollowingTransplantation in the Postnatal Colon. CellTransplantion 2019 Feb; 28(2): 157-169（IF=4.139,Q2，通讯作者，引用次数10） [12]ChenH, Qian K, Chen W,Hu B, Blackbourn LWt, Du Z, Ma L, Liu H, Knobel KM, Ayala M, ZhangSC. Human-derived neural progenitors functionally replaceastrocytes in adult mice. The Journal ofclinical investigation2015;125(3):1033-42.（IF=19.456） [13]ChenW, Jongkamonwiwat N, Abbas L, Eshtan SJ,Johnson SL, Kuhn S, Milo M, Thurlow JK, Andrews PW, Marcotti W,Moore HD, Rivolta MN. Restoration of auditory evoked responses byhuman ES-cell-derived otic progenitors. Nature2012;490(7419):278-82. （IF=69.504, 第一作者，引用次数426次） [14]BoddySL, Chen W,Romero-Guevara R, Kottam L, Bellantuono I, Rivolta MN. Inner earprogenitor cells can be generated in vitro from human bone marrowmesenchymal stem cells. Regen Med2012;7(6):757-67. （IF=3.210,Q3,共同第一作者，引用次数42） [15]ChenW, Johnson SL, Marcotti W, Andrews PW,Moore HD, Rivolta MN. Human Fetal Auditory Stem Cells Can BeExpanded In Vitro and Differentiate Into Functional AuditoryNeurons and Hair Cell-Like Cells. Stemcells 2009;27(5):1196-204. （IF=5.845,Q1，第一作者，引用次数107） [16]ChenW, Cacciabue-Rivolta DI, Moore HD, RivoltaMN. The human fetal cochlea can be a source for auditoryprogenitors/stem cells isolation. Hearingresearch 2007;233(1):23-9. （IF=3.672,Q1，第一作者，引用次数44） [17]LanL, Chen W,Lai Y, Suo J, Kong Z, Li C, Lu Y, Zhang Y, Zhao X, Zhang X, ZhangY, Han B, Cheng J, Xue Y. Monitoring of Gene Expression Profilesand Isolation of Candidate Genes Involved in Pollination andFertilization in Rice (Oryza Sativa L.) with a 10K cDNAMicroarray. PlantMolecular Biology2004;54(4):471-87. （IF=4.076, 共同第一作者，引用次数97） [18]FengQ, Zhang Y, Hao P, Wang S, Fu G, Huang Y, Li Y, Zhu J, Liu Y, HuX, Jia P, Zhang Y, Zhao Q, Ying K, Yu S, Tang Y, Weng Q, Zhang L,Lu Y, Mu J, Lu Y, Zhang LS, Yu Z, Fan D, Liu X, Lu T, Li C, Wu Y,Sun T, Lei H, Li T, Hu H, Guan J, Wu M, Zhang R, Zhou B, Chen Z,Chen L, Jin Z, Wang R, Yin H, Cai Z, Ren S, Lv G, Gu W, Zhu G, TuY, Jia J, Zhang Y, Chen J, Kang H, Chen X, Shao C, Sun Y, Hu Q,Zhang X, Zhang W, Wang L, Ding C, Sheng H, Gu J, Chen S, Ni L, ZhuF, Chen W,Lan L, Lai Y, Cheng Z, Gu M, Jiang J, Li J, Hong G, Xue Y, Han B.Sequence and analysis of rice chromosome 4. Nature2002;420(6913):316-20.（IF=49.962） [19]Chen W,Tang D, Suo J, Zhang Y, Xue Y. Expressional profiling of genesrelated to pollination and fertilization in rice. ComptesRendus de l'Académie des Sciences - Series III - Sciences de laVie 2001;324(12):1111-6. （第一作者，引用次数10） [20]. 常蕾蕾，陈燕婷， 陈伟， 程一帆， 邓桂英， 韩丽娟，黄偲元，江文静， 金佳丽，李 佳， 刘 蓉 ，茅肖鸥，马午，牛丰南， 潘洁，钱来， 邵蓓，孙芬，汤耀辉，吴建波，吴萍，汪 铮， 王柳清， 叶兰，张悦， 张梅娟，诸葛启钏，徐运，高维强，金坤林。2011，干细胞临床应用基础、伦理和原则，北京，科学出版社 专利：1.陈伟，胡珲，丁园园，李颖。一种背根神经节源的神经嵴干细胞的分离，培养和分化方法，受理号：201710668928.0，授权公告日：2020.12.22，授权公告号：CN107475200B。 2.贺永;吕尚;陈伟;傅建中。一种多尺度生物支架及其制造方法与应用，申请(专利)号：CN202110072518.6，授权公告日：2021-12-03，授权公布号：CN112915255B。 3.陆敏，陈伟。苯丙酮尿症诊断的DNA芯片。申请号,200410072621; 授权公告号：CN1696308;授权公告日：2007.02.28。
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