三、主要科研工作与成绩 （一）主持科研项目 1.STAT3/SOCS3信号通路在氧化应激诱导激素抵抗型哮喘中的作用机制研究，国家自然科学基金面上项目，项目编号：81873402，2019.1-2022.12； 2.慢性气道疾病肺功能/影像/炎症水平的规范化诊断和评估,上海市卫生系统先进适宜技术推广项目，项目编号：2019SY042，2019.7-2022.6； 3.通过深度学习的人工智能诊断模式在支气管哮喘早期诊断中的应用研究，上海市科委科创项目，项目编号：20Y11902400，2020.12-2023.12； 4.急性呼吸道传染病的早期识别与重症预警研究，上海市科委科创项目子课题，项目编号：20Z11900903，2020.12-2024.12； 5.上海市第一人民医院特色人才培养计划-上海领军人才；项目编号：02.06.01.21.13；2021.12.31-2024.12.31 6.基于症状问卷﹑肺功能﹑全身及气道炎症指标﹑影像大数据深度学习/人工智能在支气管哮喘疗效预判及急性发作预警中的作用；项目编号：CTCCR-2021B07；2021.12.01-2024.12.01 （二）代表性论文 1.Guogang Xie#, Fengming Ding#, Lei Han#, Dongning Yin, Hongzhou Lu,MinZhang*.The role of peripheral blood eosinophil counts in COVID-19patients. Allergy. 2021 Feb;76(2):471-482. doi: 10.1111/all.14465.Epub 2020 Jul 13.(Corresponding author, IF2020:13.146, JCR: Q1) 2.Huijuan Hao#, Wuping Bao#, Yishu Xue#, Yan Zhou, Zhixuan Huang,Dongning Yin, Yingying Zhang, Pengyu Zhang, Chengjian Lv, Lei Han,Xin Zhou, Junfeng Yin, MinZhang*.Spirometric changes in bronchodilation tests as predictors ofasthma diagnosis and treatment response in patients with FEV 1≥80% predicted. J Allergy Clin Immunol Pract. 2021Aug;9(8):3098-3108.e4. doi: 10.1016/j.jaip.2021.03.015.(Corresponding author, IF2020:8.861，JCR:Q1) 3.Heng Zhang#, Di Dai#, Qianwen Hu, Fang Yang, Yishu Xue, MinZhang*,Chuanxin Huang*. Bach2 attenuates IL-2R signaling to control Treghomeostasis and Tfr development. Cell Rep.2021 May11;35(6):109096. doi: 10.1016/j.celrep.2021.109096.(Co-corresponding author, IF2020:9.423，JCR:Q1) 4.Wuping Bao#, Xue Zhang#, Chengjian Lv#, Luhong Bao, Junfeng Yin,Zhixuan Huang, Bing Wang, Xin Zhou*, MinZhang*.The Value of Fractional Exhaled Nitric Oxide and ForcedMid-Expiratory Flow as Predictive Markers of BronchialHyperresponsiveness in Adults With Chronic Cough. J Allergy ClinImmunol Pract. 2018 Jul-Aug;6(4):1313-1320. doi:10.1016/j.jaip.2017.09.026. (Corresponding author, IF: 7.55, JCR:Q1) 5.Ding F#, Han L#, Fu Q, Fan X, Tang R, Lv C, Xue Y, Tian X, ZhangM*.IL-17 Aggravates Pseudomonas aeruginosa Airway Infection in AcuteExacerbations of Chronic Obstructive Pulmonary Disease. FrontImmunol. 2022 Jan 13;12:811803. doi: 10.3389/fimmu.2021.811803. (Corresponding author, IF2020:7.561, JCR: Q1) 6.Aihua Bao#, Aying Ma#, Hui Zhang#, Lihua Qiao#, Suqin Ben, XinZhou, MinZhang*.Inducible expression of heat shock protein 20 protects airwayepithelial cells against oxidative injury involving the Nrf2-NQO-1pathway. Cell Biosci. 2020 Oct 19;10:120. doi:10.1186/s13578-020-00483-3. (Corresponding author, IF:7.133, JCR:Q1) 7.Han L#, Huang Y#, Fu Q#, Xue Y, Ding F, ZhangM*.Tracking the response to Pseudomonas aeruginosa infection inozone-induced chronic obstructive pulmonary disease mouse models.Biomed Pharmacother. 2022 Apr 19;150:112980. doi:10.1016/j.biopha.2022.112980. (Corresponding author, IF2020:6.530,JCR: Q1) 8.Xue Tian#, Guogang Xie, Hui Xiao, Fengming Ding, Wuping Bao, MinZhang*.CXCR4 knockdown prevents inflammatory cytokine expression inmacrophages by suppressing activation of MAPK and NF-κB signalingpathways. Cell Biosci. 2019 Jul 3;9:55. doi:10.1186/s13578-019-0315-x. (Corresponding author, IF:5.026, JCR:Q1) 9.Yan Zhou#, Yishu Xue#, Aihua Bao#, Lei Han, Wuping Bao, Chao Xia,Xue Tian, MinZhang*.Effect of Vitamin D Deficiency and Supplementation in Lactationand Early Life on Allergic Airway Inflammation and the Expressionof Autophagy-Related Genes in an Ovalbumin Mouse Model. J InflammRes. 2021 Aug 24;14:4125-4141. doi: 10.2147/JIR.S321642.(Corresponding author, IF2020:6.922, JCR: Q1) 10.Wuping Bao#, Xue Zhang#, Yubiao Jin#, Huijuan Hao, Fu Yang,Dongning Yin, Xi Chen, Yishu Xue, Lei Han, MinZhang*.Factors associated with the expression of ACE2 in human lungtissue: Pathological evidence from patients with normal FEV1 andFEV1/FVC. J Inflamm Res. 2021 Apr 28;14:1677-1687. doi:10.2147/JIR.S300747. eCollection 2021. (Corresponding author,IF2020:6.922, JCR: Q1) 11.Xue Y#, Zhou Y#, Bao W#, Fu Q, Hao H, Han L, Zhang X, Tian X,ZhangM*.STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVAand Ozone-induced Asthma Model with Neutrophil Infiltration. FrontMol Biosci. 2021 Oct 25;8:717962. doi: 10.3389/fmolb.2021.717962. (Corresponding author, IF2020:5.246, JCR: Q2) （三）代表性专利 1.实用新型专利：一种便携式肺功能检测台车；张旻；郝慧娟；包婺平；ZL2021 2 1731651.X 2.实用新型专利：一种用于固定气管插管的牙垫固定器；张旻；包爱华；张颖颖；谢国钢；包婺平；ZL202021186967.0 |
