三、主要科研工作与成绩 1)国家自然基金面上项目,81470471,尼古丁对血管外周脂肪的影响在动脉粥样硬化中的作用和机制研究,2015/01-2018/12,68万,在研,参加 2)国家自然基金面上项目,81370415,尼古丁诱导的腹主动脉瘤nAChRs-JNK-AP-1轴调控机制研究,2014/01-2017/12,70万,在研,参加 3)国家自然科学基金(青年),81200205,脂联素拮抗瘦素致血管细胞外基质(ECM)重构的作用研究。2013/01-2015/12,23万,已结题,主持 4)国家自然基金面上项目,30971265,PPARs在稳定易损动脉粥样硬化斑块中作用及机制的研究,2009/01-2011/12,31万,已结题,参加 5)上海交通大学医工交叉研究基金“新型冠状病毒防治攻关专项”,YG2020YQ15,无线听诊系统(StemoscopeⅡ)在2019新型冠状病毒病患者诊治中的应用研究,2020/01-2022/12,30万,在研,主持。 6)上海松江区科学技术攻关项目, 19SJKJGG21,自动款新型听诊法血压计XYZ-111用于房颤患者的血压测量和大数据管理,2020/01-2022/12,1.5万,在研,主持。 7)上海交通大学 “医工交叉基金”面上项目,YG2015MS32,新型听诊法血压计搭载手机App进行大数据血压管理,2016/01-2018/12,21万,结题,主持。 8)国家自然科学基金面上项目,82270536,瓣膜性心脏病杂音特征表示学习方法及Auscul-former诊断模型研究,2023/01-2026/12,52万,在研,主持。 9)上海交通大学毕业后医学教育培训与管理创新项目,心脏听诊的规范化培训和考核体系建设的研究,2023/01-2023/12,1万,在研,主持。
代表性研究成果和学术奖励情况(每项均按时间倒序排序) 一、期刊论文(仅不列此项时可删除该标题) 1.第一作者论文 1)J. Liu, S. Shao, Q. Wang, Z. Zhang, X. Ding, L. Zhao, J. Wang, X. Ji, Q. Dai, M. Du, Z. Zhang, Antecubital vein combined with femoral vein pathway could shorten the learning curve of simultaneous bilateral adrenal vein sampling, Journal Of Clinical Hypertension, 2024, 26(6): 635-644. 2)Y. Zhuge, L. Rong, L. Ye, J. Liu, L. Su, Z. Zhang, J. Wang, Z. Zhang, The value of the wireless stethoscope in patients with COVID-19 infection in a makeshift hospital, Biomed Eng Online. 2023; 22: 71. 3)Fan M, Wang Q, Liu J, Su L, Wang B, Xu H, Li Q, Zhang Z. Real-world evaluation of the Stemoscope electronic tele-auscultation system. Biomed Eng Online. 2022; 21: 63. 4)Zhang P#, Wang B#, Liu Y#, Fan M, Ji Y, Xu H, Xu M, Chen S, Li Q*, Zhang Z*. Lung Auscultation of Hospitalized Patients with SARS-CoV-2 Pneumonia via a Wireless Stethoscope. International journal of medical sciences. 2021; 18: 1415-22. 5)Li T, Zhang Z#, Zhang X, Chen Z, Cheng HJ, Ahmad S, Ferrario CM, Cheng CP. Reversal of angiotensin-(1-12)-caused positive modulation on left ventricular contractile performance in heart failure: Assessment by pressure-volume analysis. International journal of cardiology. 2020 Feb 15;301:135-141. 6)Zhang Z, Xi W, Wang B, Chu G, Wang F. A convenient method to verify the accuracy of oscillometric blood pressure monitors by the auscultatory method: A smartphone-based app. Journal of clinical hypertension.2019; 21(2):173-180. 7)Wu Hongjun, Wang Bingjian, Zhu Xinpu, Chu Guang, Zhang Zhi. A new automatic blood pressure kit auscultates for accurate reading with a smartphone: A diagnostic accuracy study. Medicine.2016, 95(32): e4538. 8)Zhi Zhang#, Fang Wang#, Bing-jian Wang#, Guang Chu, Qunan Cao, Bao-Gui Sun, Qiu-Yan Dai*. Inhibition of leptin-induced vascular extracellular matrix (ECM) remodelling by adiponectin. J Mol Endocrinol, 2014, 53(2): 145-154 9)Zhang Z#, Chu G#, Yin RX*. Apolipoprotein M T-778C polymorphism is associated with serum lipid levels and the risk of coronary artery disease in the Chinese population: a meta-analysis. Lipids Health Dis, 2013, 12(6): 967-983 10)Zhang Z, Chu G, Wu HX, Zou N, Sun BG*, Dai QY*. IL-8 reduces VCAM-1 secretion of smooth muscle cells by increasing p-ERK expression when 3-D co-cultured with vascular endothelial cells. Clin Invest Med, 2011, 34(3): E138-E146 11)张治,严轶文,朱彦琪,诸葛萦,戴秋艳,孙宝贵*。人外周血单个核细胞在裸鼠缺血心肌中的分化,生物医学工程学杂志,2008,25(2): 424-428 12)张治,诸葛萦,朱彦琪,严轶文,李为真, 孙宝贵*,戴秋艳。裸鼠心梗模型及外周血干细胞移植模型的建立,中国病理生理杂志, 2007,23(7):1454-1456 |