三、主要科研工作与成绩 科研项目: 国家自然科学基金(面上),基于定向调控巨噬细胞极化构建负载SDF-1的葛根素水凝胶促进“干细胞与巨噬细胞多因素协同成骨”的机制研究,2023/01-2026/12,52万元 国家自然科学基金(青年),HIF-1α/SDF-1/CXCR4信号轴在颅脑损伤时骨折加速愈合中的作用及实验研究,2016/01-2018/12,21万元 上海市科委,不做谣控人,认识沉默的杀手--骨质疏松,2021/07-2023/06,50万元 上海市科委,基于构建骨靶向HSC纳米颗粒系统递送抗衰老药物治疗骨质疏松的实验研究,2021/01-2023/12,20万元 上海市教委,上海高校中青年教师国外访学计划,2021/01-延期,20万元 上海市卫健委,上海市卫健委“优青”培养计划,2019/01-2021/12,30万元 上海市卫健委,临床研究专项,基于构建造血干细胞纳米载药系统骨靶向清除衰老细胞实现骨质疏松症的“精准”治疗,2021/01-2023/12,10万元 上海交通大学“医工交叉”,重点项目,基于调控骨免疫微环境构建一种新型水凝胶促进SDF-1与巨噬细胞协同成骨的机制研究,2023/01-2026/12,100万元 上海交通大学医学院“双百人”---研究型医师,2024/07-2027/06,100万元 上海交通大学,上海交通大学交叉学科创新人才培养基地,2024/01-2026/12,10万 长宁区科委,长宁区医学硕博士创新人才基地,2023/01-2025/12,60万元
论文: BinKong, Rui Liu, Yi Cheng, Yixuan Shang, Dagan Zhang, HongchengGu,Yuanjin Zhao, WeiXu,Structural color medical patch with surface dual-properties ofwet bioadhesion and slipperiness,Advanced Science,2022, 2203096 ZhikunLi, Mei Geng, Xiaojian Ye, Yunhan Ji, Yifan Li, Xiangyang Zhang,WeiXu,IRF7inhibits the Warburg effect via transcriptional suppression ofPKM2 in osteosarcoma.International Journal of BiologicalSciences.2022 Jan 1;18(1):30-42. JunyiChe, Xiaoxuan Zhang, Guangtao Gao, Yu Yang, Jingjing Gan, KaiChen, WeiXu,Yuanjin Zhao,Yeast-derived nanocarriers enable binaryreprogramming macrophages forcancer immunotherapy,NanoToday,2024,Volume 55,2024,102164. LingyuSun, Jingjing Gan, Lijun Cai, Feika Bian, WeiXu,YuanjinZhao,Multifunctional inverse opal microcarriers-based cytokinesdelivery systemwith stem cell homing capability forosteoarthritis treatment,Aggregate,2024,e537. LeiYang , Wei Yang , WeiXu ,Yuanjin Zhao , Luoran Shang ,Bio-inspired Janus microcarrierswith sequential actives release for bone regeneration,ChemicalEngineering Journal., 2023,476 ,146797. M.Li, B. Liu, Wei.Xu,L. Zhao, Z. Wang, H. He, J. Li, F. Wang, C. Ma, K. Liu,H.Zhang.Engineering Protein Coacervates into a Robust Adhesivefor Real-Time Skin Healing,Engineering.,2023 ChiZhang; Wei Zhang; Dashuai Zhu; Zhenhua Li; Zhenzhen Wang; JunlangLi; Xuan Mei; WeiXu;Biao Zhong; Ke Cheng,Nanoparticlesfunctionalized with stem cell secretome and CXCR4 endothelialmembrane for targeted osteoporosis therapy,J.Nanobiotechnology,(2022)20:35 2022 Jan 15;20(1):35. LeiYang, Xiaocheng Wang, Yunru Yu, Luoran Shang, WeiXu,Yuanjin Zhao,Bio-inspired dual-adhesive particles frommicrofluidic electrospray for bone regeneration,NanoResearch,2022 YonggangLiu, Feifei Liu, Yani Qiu, Zhikun Li, Qin Wei, Naiyin Zhang,Chuang Ma, WeiXu,Yingbo Wang, Potent antibacterial fifibers with the functional“triad” of photothermal, silver, and Dex for boneinfections,Materials and Design,2022, ,111153. WeiXu,Yifan Li , Xiaojian Ye, Yunhan Ji, Yu Chen, Xiangyang Zhang andZhikun Li;TMED3/RPS15AAxis promotes the development and progression ofosteosarcoma.,Cancer Cell International (2021) 21:630.
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