叶晓健-硕士研究生指导教师

发布者:董尹发布时间:2025-04-24浏览次数:10

姓名

叶晓健

职称

主任医师

导师资格

博士研究生导师

学科专业

生物医学工程

联系方式

电话:13701782606

E-mailyexj2002@163.com

一、个人简介

叶晓健,上海交通大学医学院附属同仁医院骨科主任,虹桥国际医学研究院副院长,上海交通大学脊柱微创研究中心主任,主任医师、教授、博士及博士后导师,著名脊柱外科及脊柱微创专家,入选上海市医德楷模,上海区域名医,长宁工匠,长宁最美退役军人。带领团队创建上海交大脊柱微创研究中心,与交大医疗机器人研究院共同创建上海市重点实验室,打磨智能微创数字化技术用于脊柱疑难疾病诊治,开展了腰椎峡部裂螺钉固定、腰椎侧前方微创融合与内镜组合杂交技术、颈椎内镜手术等创新术式,承担包括国家重点研发计划课题3项以及国家自然科学基金4项,承担上海市科委等省部级项目、交大医工交叉项目等课题8项,发表SCI论文60余篇、主编专著7部,拥有二十余项发明专利,获得国家科技进步三等奖、上海市科技进步奖二等奖、上海医学科技三等奖和军队科技进步奖和医疗成果二等奖等奖项7项。培养硕、博士研究生和博士后逾60名。

二、主要学习与工作经历

学习经历:

1982-09- 1987-06 第二军医大学医疗系 学士

1991-09- 1996-06 第二军医大学骨外科学 博士

工作经历:

1987-07- 1991-08  济南军区总医院骨科医师

1996-07- 2011-04  第二军医大学附属长征医院骨科主任医师

2011-04- 2020-06  第二军医大学附属长征医院骨科医院副院长

2020-06- 至今 上海市同仁医院 主任医师,虹桥研究院副院长

三、主要科研工作与成绩

()近五年承担课题与基金

国家重点研发计划“主动健康和老龄化科技应对”主题“老年疼痛控制的技术研究(2020YFC2008400485万,2020-2023

上海交通大学医工交叉项目:腰椎纤维环缺损组织工程封堵器的研制与应用100万,2021-2023

上海交通大学脊柱微创研究中心150万,2021-2024

上海市科委项目:混合型颈椎病新型颈椎内镜与手术技术研究,30万,2022-2025

长宁区卫健委重点专科:骨科重点专科,100万,2024-2026-


士研究生指导教师叶晓健



































(二)近五年文章

  1. HuangX, He W, Wang W, Fan Q, Ye X, Wu Z, Lin CY. Toxicology andPharmacokinetics Study of Intradiscal Injection of Simvastatin inRabbits. Front Pharmacol 2021, 12(null): 582309.

  2. LiuY, Tang GK, Wang WH, Shi CG, Wang S, Yu L, Yu JM, Ye XJ.Morphology of Herniated Disc as a Predictor for Outcomes ofPosterior Percutaneous Full-endoscopic Cervical Discectomy inTreating Cervical Spondylotic Radiculopathy. Orthop surg 2021,13(8): 2335-2343.

  3. HuangX, Zheng C, Wang W, Ye X, Lin CY, Wu Z. The Effect and PossibleMechanism of Intradiscal Injection of Simvastatin in theTreatment of Discogenic Pain in Rats. Front Neurosci 2021, 15:642436.

  4. LiuY, Wang Y, Xiao B, Tang G, Yu J, Wang W, Xu G, Ye X.pH-responsive delivery of H2 through ammonia borane-loadedmesoporous silica nanoparticles improves recovery after spinalcord injury by moderating oxidative stress and regulatingmicroglial polarization. Regen biomater 2021.

  5. ShiC, Sun B, Tang G, Xu N, He H, Ye X, Xu G, Gu X. Clinical andradiological outcomes of endoscopic foraminoplasty anddecompression assisted with preoperative planning software forlumbar foraminal stenosis. Int j comput ass rad 2021, 16(10):1829-1839.

  6. ShiC, Xu N, Sun B, Chen R, He H, Xu G, Ye X, Gu X. Clinical Outcomesof Posterior Percutaneous Endoscopic Cervical Foraminotomy andDiscectomy Assisted with SNRB in Treating Cervical Radiculopathywith Diagnostic Uncertainty. Pain physician 2021, 24(4):E483-e492.

  7. TangG, Liu Z, Liu Y, Yu J, Wang X, Tan Z, Ye X. Recent Trends in theDevelopment of Bone Regenerative Biomaterials. Front Cell DevBiol 2021, 9: 665813.

  8. XuC, Luo S, Wei L, Wu H, Gu W, Zhou W, Sun B, Hu B, Zhou H, Liu Y,Chen H, Ye X, Yuan W. Integrated transcriptome and proteomeanalyses identify novel regulatory network of nucleus pulposuscells in intervertebral disc degeneration. BMC Med Genomics 2021,14(1): 40.

  9. XuW, Li Y, Ye X, Ji Y, Chen Y, Zhang X, Li Z. TMED3/RPS15A Axispromotes the development and progression of osteosarcoma. CancerCell Int 2021, 21(1): 630.

  10. YuL, Liu Y, Wu J, Wang S, Yu J, Wang W, Ye X. Genipin Cross-LinkedDecellularized Nucleus Pulposus Hydrogel-Like Cell DeliverySystem Induces Differentiation of ADSCs and RetardsIntervertebral Disc Degeneration. Front Bioeng Biotechnol 2021,9: 807883.

  11. HanY, Zhou Y, Li H, Gong Z, Liu Z, Wang H, Wang B, Ye X, Liu Y.Identification of diagnostic mRNA biomarkers in whole blood forankylosing spondylitis using WGCNA and machine learning featureselection. Front Immunol 2022, 13: 956027.

  12. LiZ, Geng M, Ye X, Ji Y, Li Y, Zhang X, Xu W. IRF7 inhibits theWarburg effect via transcriptional suppression of PKM2 inosteosarcoma. Int J Biol Sci 2022, 18(1): 30-42.

  13. LiuX, Li T, Wang F, Sun F, Hu J, Ye X, Wang D, Yang X. Controllingsustained statins release in multi-layered composite scaffoldsfor healing of osteoporotic bone defects. Biomater Adv 2022, 137:212838.

  14. WangJ, Li Y, Gao Y, Ye X. Effect of Doped Functional Bioceramic on invitro Degradation and Histocompatibility ofPoly(L-lactide-trimethylene carbonate-glycolide) Terpolymers.Mater Today Commun 2022: 103616.

  15. WangW, Tang L, Zhang G, Xiao B, Xi Y, Gu X, Ye X. PostoperativeUpper-limb Palsy After Posterior Percutaneous Endoscopic CervicalForaminotomy and Discectomy. Pain physician 2022, 25(8):E1289-e1296.

  16. WangW, Xiao B, Wang H, Qi J, Gu X, Yu J, Ye X, Xu G, Xi Y. Obliquelateral interbody fusion stand-alone vs. combined withpercutaneous pedicle screw fixation in the treatment ofdiscogenic low back pain. Front Surg 2022, 9: 1013431.

  17. LiY, Wang S, Zhu Z, Chen L, Shi Z, Ye X, Xu W, Li Z. BiomechanicalAnalysis of Cortical Bone Trajectory Screw Versus Bone CementScrew for Fixation in Porcine Spinal Low Bone Mass Model. Clinspine surg 2023, 36(4): E145-e152.

  18. LiZ, Li Y, Xu W, Yu J, Tong S, Zhang X, Ye X. 3D-printedpolyether-ether-ketone/n-TiO2 composite enhances thecytocompatibility and osteogenic differentiation of MC3T3-E1cells by downregulating miR-154-5p. Open Med (Wars) 2023, 18(1):20230636.

  19. LiuY, Xue M, Han Y, Li Y, Xiao B, Wang W, Yu J, Ye X. Exosomes fromM2c macrophages alleviate intervertebral disc degeneration bypromoting synthesis of the extracellular matrix viaMiR-124/CILP/TGF-β. Bioeng Transl Med 2023, 8(6): e10500

  20. ShiC, Xi Y, Sun B, He H, Wen J, Ruan Y, Ye X. Suspected allergy totitanium after anterior cervical discectomy and fusion using aZero-P device: a case report. Brit j neurosurg 2023, 37(4):916-920.

  21. WuJ, Yu L, Liu Y, Xiao B, Ye X, Zhao H, Xi Y, Shi Z, Wang W.Hypoxia regulates adipose mesenchymal stem cells proliferation,migration, and nucleus pulposus-like differentiation byregulating endoplasmic reticulum stress via the HIF-1α pathway.J Orthop Surg Res 2023, 18(1): 339.

  22. XiY, Pan W, Liu Y, Liu J, Xu G, Su Y, Chen D, Ye X. α-Lipoic acidloaded hollow gold nanoparticles designed for osteoporosistreatment: preparation, characterization and in vitroevaluation. Artif cell nanomed b 2023, 51(1): 131-138.

  23. ZhangD, Li X, Li J, Liu W, Yu Y, Wang S, Ye X. Casticin promotesosteogenic differentiation of bone marrow stromal cells andimproves osteoporosis in rats by regulating nuclearfactor-κB/mitogen-activated protein kinase. Int j rheum dis2023, 26(1): 80-87.

  24. LiY, Wei Z, Chai B, Pan Z, Zhang S, Li H, Wang J, Ye X. Highlyadhesive self-reinforce hydrogel for the amelioration ofintervertebral disc degeneration: Eliminating reactive oxygenspecies and regulating extracellular matrix. Compos part b-eng2024,: 111280.

  25. WangJ, Ye H, Zhou B, Pan Z, Li Y, Wei Z, Chai B, Gao Y, Ye X, Yu J.Biomimetic nanofibrillar/hyaluronic acid hydrogels remodel theneuromodulatory microenvironment for enhanced bone regeneration.Chinese chem lett 2024: 110133.

  26. WeiZ, Ye H, Li Y, Li X, Liu Y, Chen Y, Yu J, Wang J, Ye X.Mechanically tough, adhesive, self-healing hydrogel promotesannulus fibrosus repair via autologous cell recruitment andmicroenvironment regulation. Acta biomater 2024, 178: 50-67.

  27. ZhangD, Li J, Li X, Liu W, Yu Y, Sun H, Wu J, Ge Z, Lv K, Shao Y, WangS, Ye X. Anti-osteoporosis activity of casticin in ovariectomizedrats. Toxicol res-uk 2024, 13(2): tfae064.

  28. TangGuoke, Li, Yucai, Liu Yi, Lin Lan, Wang Jielin, Wang Xing, YeXiaojian,. Robustly Injectable Tetra-PEG Hydrogel Sealants forAnnulus Fibrosus Repair. Adv Healthc Mater 2025Jan;14(3):e2403163

  29. YujieChen, Wei Xu, Zhen Pan, Bohui Li, Xiumei Mo, Yucai Li, JielinWang, Yuan Wang, Zhenyuan Wei, Yicheng Chen, Zhaopu Han, ChenLin, Yu Liu, Xiaojian Ye, Jiangming Yu. Three-DimensionalGas-Foamed Scaffolds Decorated with Metal Phenolic Networks forCartilage Regeneration . Materials Today Bio, 2024, 29: 101249.

  30. YujieChen, Yucai Li, Xinyi Wang, Xiumei Mo, Yicheng Chen, Zijun Deng,Xiaojian Ye, Jiangming Yu. One-Step Gas Foaming Strategy forConstructing Strontium Nanoparticle Decorated 3D Scaffolds: A NewPlatform for Repairing Critical Bone Defects [J]. ACS AppliedMaterials & Interfaces, 2024, Online,doi.org/10.1021/acsami.4c13119.

  31. GanLin, Zhao Chaoqian, Chen Haojie, Li Yucai, Pan Zhen, Li Yan, WangXiao, Wang jielin, Yu Jiangming, Ye Xiaojian. 3D printed β-TCPscaffolds loaded with SVVYGLR peptide for promotingrevascularization and osteoinduction. Biomedical Materials, 2024Dec 6;20(1).

  32. HanZhaopu, Chen Yicheng, Ye Xiaojian. The causality between smokingand intervertebral disc degeneration mediated by IL-1β secretedby macrophage: A Mendelian randomization study. Heliyon, 2024 Sep15;10(17):e37044.

  33. ZhenyuanWei, Xiaoxiao Li, Yicheng Chen, Zhaopu Han, Yan Li, Lin Gan, YangYang, Yujie Chen, Feng Zhang,Xiaojian Ye,and WenguoCui.Programmable DNA-Peptide Conjugated Hydrogel via ClickChemistry for Sequential Modulation of Peripheral NervRegeneration,Adv. Funct. Mater. 2025, 2419915

  34. Yong,Xu;  Xin, Gu;  Xingchen, Li;  Yicheng,Chen;  Zhenyuan, Wei;  Jielin, Wang;  Yi,Liu;  Yunhan, Ji;  Qian, Cheng;  Shuai,Jiang;  Jiangming, Yu;  Xiaoxiao,Li;  Wenguo, Cui;  XiaoJian, Ye,β-DiketoneFunctionalized Microspheres Chelate Reactive Iron via MetalCoordination for Cartilage Repair.Adv Healthc Mater 2025Apr;14(10):e2403933.




(三)近五年专利

1.发明专利:

强粘附可注射透明质酸双网络水凝胶及其制备方法ZL2022 1 1601157.0

2.实用新型专利:

一种新型峡部裂修复融合器ZL2023 2 0701474.3

一种简易经皮胸腰椎椎体活检套装ZL2023 2 0519029.5

一种用于椎间孔镜下腰椎融合手术的可扩张通道ZL2022 2 2201507.6

一种可调节的内窥镜管道系统ZL2023 2 0550064.3

一种新型腰椎皮质骨螺钉置入导向器ZL2022 2 3189826.6

一种可伸展的多向手术钳ZL2023 21016662.9

一种搭载椎弓根螺钉的深部软组织牵开器ZL2023 20530001.1

一种可调节方向的手动镜下软组织清理器ZL2023 20530000.7


(四)近五年专著

1.主编《导航脊柱外科手术学》,2021,上海科技出版社

2.主编《现代骨科手术技巧与并发症的防范处理》,2021,天津科学技术出版社

3.主编《经皮脊柱内镜手术精要》,2021,人民卫生出版社

4.《微创脊柱手术器械研究与应用》,2023,辽宁科学技术出版社


四、主要社会学术团体兼职

  1. 上海市医学会骨科专业委员会委员兼微创学组第一、第二届组长

  2. SOLAS中国部副主任委员

  3. SICOT中国部脊柱微创学会副主任委员

  4. 国际及亚太脊柱微创学会委员

  5. 中国医师协会内镜医师分会脊柱内镜专业委员会副主任委员

  6. 中国研究型医院学会脊柱外科分会脊柱微创学组组长

  7. 中国康复医学会脊柱脊髓专委会数字脊柱外科学组副组长

  8. 中国研究型医院学会转化与创新分会数字化脊柱微创专委会副主委

  9. 海峡两岸医药卫生交流协会脊柱微创专业委员会副主任委员

  10. 中华医学会骨科分会脊柱微创学组委员

  11. 中国康复医学会脊柱脊髓专业委员会微创学组委员

  12. 解放军骨科专业委员会脊柱微创学组副组长

  13. 中国老年学与老年医学学会骨质疏松专委会常委兼脊柱微创学组副组长

  14. 中国残疾人康复协会脊髓损伤康复专业委员会常委

  15. 上海中西医结合学会脊柱专委会副主任委员兼微创学组组长

  16. 上海医师协会骨科分会脊柱微创学组副组长

  17. 上海市康复医学会骨科康复专业委员副主任委员

  18. 《脊柱外科杂志》常务副主编、编辑部主任

  19. SICOT上海分会副主任委员

  20. 中国老年保健学会骨科微创分会副会长

  21. 中国研究型医院学会颈椎疾病健康管理与加速康复专业委员会常务委员

  22. 中国医师协会骨科医师分会委员会脊柱微创学组委员

  23. 中国医师协会骨科医师分会继续教育学组委员

  24. 上海市医学会骨科专科分会委员

  25. 上海市医师协会骨科医师分会委员

  26. 上海市康复医学会第四届脊柱脊髓专业委员会主任委员

  27. 上海市康复医学工程研究会第八届理事会常务理事

  28. 中国医师学会内镜医师分会常务委员兼脊柱内镜专委会副主任委员

  29. 上海市中西医结合学会脊柱专委会常务委员


五、主要研究方向

  1. 脊柱微创与手术机器人研发

  2. 脊柱微创与生物修复材料开发

  3. 脊柱微创精准外科决策体系构建

  4. 脊柱手术效果动态评估与预后优化