三、主要科研工作与成绩 科研论文： WangJ, Liu L, Gao X, Liu X, Dai Y, Mao Z, Huang S, Li J, Wang D, QiY, Han Y, Xu Y, Chua CYX, Grattoni A, Xie W*, YangH*,Huang G*. A novel pathway for stemness propagation andchemoresistance in non-small cell lung cancer via phosphorylatedPKM2-loaded small extracellular vesicles. Theranostics 2025;15(8):3439-3461. 高心雨,毛子俊,黄圣喆,黄钢,杨浩*.肿瘤干细胞源性的外泌体促进结直肠癌细胞的化疗耐药和侵袭.中国生物化学与分子生物学报:1-17 [2024-06-19，封面论文]. LiH#, YangH#, LiuJ, Yang H, Gao X, Yang X, Liu Z, Qian Q. Adipose stemcells-derived small extracellular vesicles transportThrombospondin 1 cargo to promote insulin resistance ingestational diabetes mellitus. Diabetol Metab Syndr.2024;16(1):105. HuJ-L, Guo Z-J, Wang C, Yan J, YangH*.Ovarian serous carcinoma with stomach metastasis: a rare casereport and literature review. Journal of International MedicalResearch. 2024;52(4): 3000605241245000. YangH, ZhaoX, Liu J, Jin M, Liu X, Yan J, Yao X, Mao X, Li N, Liang B, XieW, Zhang K, Zhao J*, Liu L*, Huang G*. TNFα-induced IDH1hyperacetylation reprograms redox homeostasis and promotes thechemotherapeutic sensitivity. Oncogene. 2023, 42(1):35-48. ChangY, Gao X, Jiang Y, Wang J, Liu L, Yan J, Huang G*,Yang H*.Alpha-hederin reprograms multi-miRNAs activity and overcome smallextracellular vesicles-mediated paclitaxel resistance in NSCLC.Front Pharmacol. 2024; 15:1257941. YangH*,Wang J, Huang G*. Small extracellular vesicles in metabolicremodeling of tumor cells: Cargos and translational application.Front Pharmacol. 2022, 13:1009952. DaiY, Liu Y, Li J, Jin M, YangH*,Huang G*. Shikonin inhibited glycolysis and sensitized cisplatintreatment in non-small cell lung cancer cells via the exosomalpyruvate kinase M2 pathway. Bioengineered. 2022,13(5):13906-13918. WangD, Zhao C, Xu F, Zhang A, Jin M, Zhang K, Liu L, Hua Q, Zhao J,Liu J, YangH*,Huang G*. Cisplatin-resistant NSCLC cells induced by hypoxiatransmit resistance to sensitive cells through exosomal PKM2.Theranostics. 2021, 11(6):2860-2875. YangH,Zheng H, Pan Y, Zhang W, Yang M, Du H, Yu A, Li P, Chen X, Xie W,Ren K, Zhao Y, Wang T, He X*, Zhou Z*. Quantitative proteomicanalysis of the effects of dietary deprivation of methionine andcystine on A549 xenograft and A549 xenograft-bearing mouse.Proteomics. 2021, 21(20):e2100007. XuF, Hua Q, Zhang A, Zhang D, Wang Y, Zhao L, YangH*, LiuJ*, Huang G*. LncRNA AC020978 facilitates non-small cell lungcancer progression by interacting with MDH2 and activating AKTpathway. Cancer Sci. 2021, 112(11): 4501-4514. YangH*, XieS, Liang B, Tang Q, Liu H, Wang D, Huang G*. Exosomal IDH1increases the resistance of colorectal cancer cells to5-Fluorouracil. J Cancer. 2021, 12(16):4862-4872. YangH, ChenY, Jiang Y, Wang D, Yan J*, Zhou Z*. TP53 mutation influences theefficacy of treatment of colorectal cancer cell lines with acombination of sirtuin inhibitors and chemotherapeutic agents.Exp Ther Med. 2020, 20(2): 1415-1422. YangH, ZhuR, Zhao X, Liu L, Zhou Z, Zhao L, Liang B, Ma W, Zhao J, Liu J*,Huang G*. Sirtuin-mediated deacetylation of hnRNP A1 suppressesglycolysis and growth in hepatocellular carcinoma. Oncogene.2019, 38(25):4915-4931.
主持项目： 国家自然科学基金项目面上项目，PKM2苏木化修饰调节非小细胞肺癌起始细胞介导的耐药生态位的机制研究，2024年1月-2027年12月 上海市自然科学基金面上项目，小细胞外囊泡传递磷酸化IGFBP3调控结直肠癌代谢稳态及化疗敏感性的基础研究，2023年4月-2026年3月 国家自然科学基金项目青年科学基金项目，SIRT1去乙酰化IDH1调节结直肠癌糖代谢重编程及耐药性的机制研究，2020/1-2022/12 上海市教委上海高校青年教师培养资助计划，课程思政改革要求下医学生物化学课程的课堂教学设计，2019/7-2020/12 上海健康医学院种子基金项目（自然科学类），乙酰化的hnRNPA1通过PKM2调节肝癌细胞糖代谢的机制研究，2018/01-2019/12 上海健康医学院师资人才百人库项目，异柠檬酸脱氢酶1在KRAS突变结直肠癌化疗耐药中的功能研究，2019/01-2019/12 上海市A类“晨光计划”项目，IDH1及其去乙酰化在KRAS突变结直肠癌化疗耐药中的作用研究，2020/01-2022/12 上海健康医学院科研骨干校外导师制（AcademicMentorship for Scientific Research CadreProject），去乙酰化酶在5-氟尿嘧啶耐药的结直肠癌中的功能与机制研究，2021/01-2023/12
9. 上海市教委“教师专业发展工程”的产学研践习计划，基于肿瘤外泌体中代谢成分进行肿瘤微环境监测的的分子影像技术开发，2021年3月-2022年2月 |
