林丹-硕士研究生指导教师

发布者：董尹发布时间：2025-04-28浏览次数：10

姓名

林丹




职称

讲师

导师资格

硕导

学科专业

生物医学工程，生物医学工程（医学），医学技术，电子信息（生物医学方向），口腔医学技术

联系方式

电话：13671777375

E-mail：lind@sumhs.edu.cn

一、个人简介

林丹，女，上海健康医学院口腔医学技术专业讲师、硕导，生物医用材料博士、口腔基础医学博士后，主要研究方向包括骨修复材料、骨再生、口腔材料、数字化口腔医学技术、口腔医学有限元分析等。先后主持上海市扬帆计划、中国博士后科学基金特别资助、国家自然科学基金等多项科研项目。近五年一作/通讯发表SCI论文13篇，其中IF>10的9篇，影响因子总和超160。

以人为本，亦师亦友，研究方向丰富多样，课题方向选择可契合学生个人发展，愿与学生共同成就，合作共赢。

二、主要学习与工作经历

学习经历：

2012/9 – 2018/6 华东理工大学，材料学院，博士

工作经历：

2018/7 – 2021/8 上海交通大学医学院附属第九人民医院，博士后

2021/9 – 今 上海健康医学院，医学技术学院，讲师/硕导

三、主要科研工作与成绩

科研项目

  1. 国家自然科学基金委员会，青年项目，32201104，干细胞源外泌体/介孔生物玻璃支架促进老龄骨再生及其转录组学作用机制研究，2023/01-2025/12，30万元，在研，主持

  2. 上海市科学技术委员会，地方院校能力建设项目，22010502600，AI赋能下的骨质疏松精准诊疗及口腔植骨材料辅助康复，2022/03-2025/02，40万，在研，参与

  3. 中国博士后科学基金，第13批特别资助（站中），2020T130422，促成骨的干细胞源外泌体筛选、应用及其基于lncRNA-miRNA-mRNA共表达网络的机制研究，2020/08 至 2021/08，18万元，结题，主持

  4. 国家自然科学基金委员会，面上项目，81970973，核壳梯度粘弹性PEGS/MBG双相支架引导髁突缺损原位一体化修复再生的基础应用研究，2020/01-2023/12，55万元，已结题，参与

  5. 上海市科学技术委员会，青年科技英才扬帆计划，19YF1425500，3D打印与自组装相结合构建多级微纳仿生骨修复支架，2019/05-2022/04，20万元，已结题，主持

论文发表

  1. Dong X, Liu X, Lin D*, Zhang L, Wu Y, Chang Y, Jin M*, Huang G*. Baicalin induces cell death of non-small cell lung cancer cells via MCOLN3-mediated lysosomal dysfunction and autophagy blockage. Phytomedicine, 2024, 133, 155872. (IF: 7.9)

  2. Wang Z, Lao A, Huang X, Zhou Y*, Steve GF Shen*, Lin D*. Apt-19s-Functionalized 3D-Printed Mesoporous Bioactive Glass Scaffold Promotes BMSC Recruitment in Bone Regeneration via SDF-1α/CXCR4 Axis and MAPK Signaling. Advanced Functional Materials, 2024, 2316675. (IF: 19.924)

  3. Ma M, Shen W, Li B, Sun M, Lin D*, Meng L*. Optimization of a concentrated growth factor/mesoporous bioactive glass composite scaffold and its application in rabbit mandible defect regeneration. Biomater. Sci., 2023,11, 6357-6372. (IF: 7.590)

  4. Shi Y, Wang J, Ma C, Shen J, Dong X*, Lin D*. A Systematic Review of the Accuracy of Digital Surgical Guides for Dental Implantation. International Journal of Implant Dentistry, 2023, 9:38. (IF: 2.76)

  5. Qi L, Ge W, Pan C, Jiang W, Lin D*, Zhang L*. Compromised osteogenic effect of exosomes internalized by senescent bone marrow stem cells via endocytoses involving clathrin, macropinocytosis and caveolae. Front Bioeng Biotechnol. 2023 Jan 4;10:1090914. (IF: 6.064)

  6. Wang Z, Lin D*, Wang M, et al. Seamless route of self-assembly and 3D printing to fabricate hierarchical mesoporous bioactive glass scaffold for customized bone regeneration with enhanced efficacy. Chemical Engineering Journal, 2022, 446, 137270. (IF: 16.744)

  7. Zhao H#, Wang X#, Jin A, Wang M, Wang Z, Huang X, Dai J*, Wang X*, Lin D*, Steve GF Shen*. Reducing relapse and accelerating osteogenesis in rapid maxillary expansion using an injectable mesoporous bioactive glass/fibrin glue composite hydrogel. Bioactive Materials, 2022, 18:507-525. (IF: 16.874)

  8. Cai B#, Lin D#*, Li Y#, et al. N2-polarized neutrophils guide BMSC recruitment and initiate bone regeneration: A missing piece of the bone regeneration puzzle. Advanced Science, 2021, 2100584. (IF: 17.521)

  9. Liu A, Lin D *, Zhao H, et al. Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor-activated Smad pathway. Biomaterials, 2021, 120718. (IF: 15.304)

  10. Wang X#, Zhao H#, Liu Z, Wang Y, Lin D, et al. Polydopamine nanoparticles as dual-task platform for osteoarthritis therapy: a scavenger for reactive oxygen species and regulator for cellular powerhouses. Chemical Engineering Journal, 2021, 417, 129284. (IF: 16.744)

  11. Lin D#, Cai B#, Wang L, et al. A viscoelastic PEGylated poly(glycerol sebacate)-based bilayer scaffold for cartilage regeneration in full-thickness osteochondral defect. Biomaterials, 2020, 253, 120095. (IF: 15.304)

  12. Lin D, Chai Y, Ma Y, et al. Rapid initiation of guided bone regeneration driven by spatiotemporal delivery of IL-8 and BMP-2 from hierarchical MBG-based scaffold. Biomaterials, 2019, 196, 122-137. (IF: 15.304)

  13. Lin D, Zhang J, Bai F, et al. Fabrication and clinical application of easy-to-operate pre-cured CPC/rhBMP-2 micro-scaffolds for bone regeneration. American Journal of Translational Research, 2016, 8(3), 1379-1396. (IF: 3.94)

  14. Lin D, Yang K, Tang W, et al. A poly(glycerol sebacate)-coated mesoporous bioactive glass scaffold with adjustable mechanical strength, degradation rate, controlled-release and cell behavior for bone tissue engineering. Colloids & Surfaces B Biointerfaces, 2015, 131, 1-11. (IF: 5.999)

  15. Huang J, Lin D, Wei Z, et al. Parathyroid Hormone Derivative with Reduced Osteoclastic Activity Promoted Bone Regeneration via Synergistic Bone Remodeling and Angiogenesis. Small, 2020, 1905876. (IF: 15.153)

  16. Tang W, Lin D, Yu Y, et al. Bioinspired trimodal macro/micro/nano-porous scaffolds loading rhBMP-2 for complete regeneration of critical size bone defect. Acta Biomaterialia, 2016, 32, 309-323. (IF: 10.633)

  17. Cai L, Lin D, Chai Y, et al. MBG scaffolds containing chitosan microspheres for binary delivery of IL-8 and BMP-2 for bone regeneration. Journal of Materials Chemistry B, 2018, 6, 4453-4465. (IF: 7.571)

  18. Chai Y, Lin D, Ma Y, et al. RhBMP-2 loaded MBG/PEGylated poly(glycerol sebacate) composite scaffolds for rapid bone regeneration. Journal of Materials Chemistry B, 2017, 5, 4633-4647. (IF: 7.571)

  19. Niu H, Lin D, Tang W, et al. Surface topography regulates osteogenic differentiation of MSCs via crosstalk between FAK/MAPK and ILK/β-catenin pathways in a hierarchically porous environment. ACS Biomaterials Science & Engineering, 2017, 3, 3161-3175. (IF: 5.395)

  20. Yuan Y, Lin D, Chen F, et al. Clinical translation of biomedical materials and the key factors towards product registration. Journal of Orthopaedic Translation, 2014, 2(2), 49-55. (IF: 4.889)

  21. Zhang J, Ma X, Lin D, et al. Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism. Biomaterials, 2015, 53, 251-264. (IF: 15.304)

  22. Tang W, Yuan Y, Lin D, et al. Kaolin-reinforced 3D MBG scaffolds with hierarchical architecture and robust mechanical strength for bone tissue engineering. Journal of Materials Chemistry B, 2014, 2(24), 3782-3790. (IF: 7.571)

  23. Yu Y, Chen J, Chen R, Tang W, Lin D, et al. Enhancement of VEGF-Mediated Angiogenesis by 2-N,6-O-Sulfated Chitosan-Coated Hierarchical PLGA Scaffolds. ACS Applied Materials & Interfaces, 2015, 7(18), 9982-9990. (IF: 10.383)

  24. Wang X, Kwak K J, Yang Z, Lin D, et al. Extracellular mRNA detected by molecular beacons in tethered lipoplex nanoparticles for diagnosis of human hepatocellular carcinoma. Plos One, 2018, 13(6), e0198552. (IF: 3.752)

  25. Ma Y, Huang B, Lin D, et al. Bioactivation of Calcium Phosphate Cement by Growth Factors and Their Applications. Developments and Applications of Calcium Phosphate Bone Cements. 2018.

  26. 赵涵江, 王泽莹, 林丹, 沈国芳. 纤维蛋白凝胶对上颌扩弓成骨矿化的影响. 中国口腔颌面外科杂志, 2021, 19(5):8.

授权专利

  1. 林丹, 一种3D打印自组装的介孔生物玻璃多孔支架的方法. CN202210571078.3

  2. 林丹, 一种采用高粘度溶胶3D打印介孔生物玻璃支架的方法. CN202210572368.X.

  3. 刘昌胜, 林丹, 柴延军, 袁媛. 人骨形态发生蛋白-2复合材料及其制备方法和应用, CN201610392378.X.

  4. 刘昌胜, 林丹, 杨凯, 袁媛. 一种介孔生物玻璃/聚癸二酸甘油酯复合支架及其制备方法和应用, CN2015101075743.

  5. 刘昌胜, 袁媛, 唐为, 林丹, 牛浩一. 高强度多级微纳结构硅基骨修复支架材料、其制备方法及应用, CN2013107238158.

四、主要社会学术团体兼职

无

五、主要研究方向

1、骨修复材料，骨组织再生
2、口腔材料，数字化口腔医学技术，口腔医学有限元分析

六、全日制专业学位联合培养单位

上海理工大学，医学技术/生物医学工程/生物医学工程（医学）/电子信息（生物医学方向）