Qingrong Huang (Professor)
(Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901, USA)
时间：2025年6月18日，9:00-11:00
地点：上海理工大学卓越楼1110会议室
Abstract:
Polymethoxyflavones (PMFs) are a unique group of flavonoids that abundantly exist in the citrus peels. Multiple health benefits including anti-inflammation, anti-cancer, anti-diabetes and anti-obesity properties have been reported for PMFs. Our previous cell and mouse studies demonstrated that PMFs could attenuate obesity through AMP-activated protein kinase (AMPK) signaling. In this talk, we will discuss the mechanism underlying the anti-obesity activities using high-fat diet (HFD) induced obese mice fed with PMFs. We found that PMFs could significantly increase fecal short chain fatty acids, decrease Proteobacteria prevalence and the ratio of Firmicutes to Bacteroidetes, and significantly and dynamically promote beneficial bacteria, such as Akkermansia spp. and Allobaculum spp. The pharmacokinetic study demonstrated that the oral bioavailability of PMFs can be improved by ~20% by encapsulation using nanoemulsions. For the key PMFs component nobiletin, the major metabolites included 3'-demethylnobiletin (3'DMN), 4'-demethylnobiletin (4'DMN), and 3',4'-didemethylnobiletin (3'4'DDMN). Other mono-demethylated-nobiletins (DMNs) were also detected in pharmacokinetic and bio-efficacy studies. However, because of the lack of standards, the demethylation positions were not previously identified. We have successfully developed an efficient synthetic method for 6DMN and 7DMN using microbes isolated from aged citrus peels. 6DMN was found to be more potent in suppressing lipogenesis than 7DMN.
Biography:
Dr. Qingrong Huang is currently a Professor at the Department of Food Science, Rutgers, The State University of New Jersey. He founded the first food nanotechnology lab in the USA and devoted his professional career to Food Nanotechnology and Biopolymer research. His research areas include novel functional food, nanoencapsulation technology, biopolymer nanocomposite material, and biological nanotechnology. He is the 2017-2024 Clarivate Analytics Highly Cited Researcher in Agricultural Science and the most cited author of the American Journal of Agricultural Chemistry in 2017. He was elected Fellow of the Agricultural Chemistry Department of the American Chemical Society in 2016. He has published 405 refereed journal papers in renowned journals like the Journal of the American Chemical Society, Food Hydrocolloids, Journal of Agricultural and Food Chemistry, etc. He has also published 15 book chapters and two books, such as “Micro/Nano Encapsulation of Active Food Ingredients” and “Nanotechnology in the Food, Beverage, and Nutraceutical Industries”.