团队负责人
团队成员
陈志杰、赵文婷
团队简介
研究团队主要从事健康食品创制与脑分子营养方面的相关研究，主要包括以下几个方面：（1）蛋白肽制备与功能活性评价；（2）脑分子营养机制与健康效应；（3）精准营养与健康食品创制。
代表性成果
1.科研项目
[1] 2022-2024年，国家高层次人才特殊支持计划
[2] 2024-2027年，国家自然基金-面上项目，核桃肽基于Caveolins调控细胞内吞跨血脑屏障的转运机制
[3] 2020-2023年，国家自然基金-面上项目，基于PINK1的核桃肽（HTP-7）介导线粒体自噬调节机制研究
[4] 2018-2021年，国家自然基金-面上项目，新型天冬氨酸激酶别构调控机制研究及高产蛋氨酸工程菌构建
[5] 2013-2018年，国家“863”计划子课题，坚果活性蛋白制备关键技术研究与开发
[6] 2012-2014年，国家农业成果转化资金项目，玉米功能性淀粉成果转化与产业化示范
[7] 2006-2007年，国家农业成果转化资金项目，玉米营养方便面系列产品开发
[8] 2025-2027年，国家自然科学基金-青年基金项目，新型长读长、强普适、高灵敏单分子蛋白质测序及磷酸化修饰检测技术开发
[9] 2023-2025年，中国博士后科学基金面上资助，新型单分子蛋白质测序技术研发
[10] 2024-2027年，国家科技部重点研发计划子课题，蛋白质单分子测序系统研发
[11] 2025-至今，浙江省“尖兵领雁+X”科技计划项目，活性因子挖掘与功能食品制造
[12] 2021-2024年，“吉林省长白山人才工程领军人才”项目
[13] 2023-2025年，“浙江省援疆科技特派团”项目
[14] 2021-2024年，吉林省重点研发项目，核桃粕高效利用关键技术研究与产品开发
[15] 2023-2025年，区校合作项目，山核桃采后品质劣变机理及保鲜技术研究
[16] 2017-2019年，长春市双十重大攻关项目，玉米高效生物转化蛋氨酸生产关键技术研究
[17] 2016-2018年，吉林省成果转化项目，玉米淀粉生产高效绿色浸泡技术成果转化与产业化示范
[18] 2015-2017年，吉林省中青年科技创新领军人才及团队项目，吉林省玉米生物高效转化及精深加工创新团队
[19] 2015-2017年，长春市科技攻关项目，玉米淀粉生产场辅助生物浸泡关键技术研究
[20] 2012-2015年，吉林省自然基金项目，活性肽基于NF-κB信号通路改善氧化应激的神经退行性疾病机理研究
[21] 2012-2014年，吉林省人社厅人才开发基金项目，玉米功能性淀粉成果转化与产业化示范
[22] 2011-2014年，吉林省重点攻关项目，淀粉蔗糖酶制备功能性糖的关键技术研究
[23] 2008-2011年，吉林省重点攻关项目，玉米高压复合酶法浸泡关键技术
[24] 2006-2009年，吉林省重点攻关项目，缓慢消化淀粉制备技术研究与开发
[25] 2009-2011年，长春市科技攻关项目，以玉米芯为原料生物转化木糖醇绿色生产关键技术研究
[26] 2005-2007年，吉林省重点攻关项目，生物发酵法制备高得率抗性淀粉技术研究
[27] 2024-2026年，山东省自然科学基金青年项目，基于纳米孔的新型多肽控速方法开发及其应用
2.发明专利
[1] 闵伟红；卢红妍；刘春雷；王辑；方丽，HIGH-ACTIVITY MEMORY-IMPROVING DERIVATIVE PEPTIDE AND USE THEREOF，US11780880B2
[2] 闵伟红；赵凡睿；李泽惠，具有清除Aβ1-42蛋白沉积的高抗氧化活性改善学习记忆力核桃衍生肽及其应用，ZL202411730722.2
[3] 闵伟红；李泽惠；赵凡睿；杨栋梁，一种高活性改善学习记忆力抗氧化核桃衍
生肽及其应用，ZL202410954437.2
[4] 闵伟红；赵凡睿，一种具有2019新型冠状病毒主蛋白酶抑制活性的榛仁蛋白衍生肽及其应用，ZL202310145383.0
[5] 闵伟红；党乔；赵凡睿；田雪梅；杨栋梁，一种可穿透血脑屏障改善学习记忆力的核桃衍生肽及其应用，ZL202311161773.3
[6] 闵伟红；赵凡睿；刘春雷；方丽；王辑；卢红妍，一种保护神经细胞氧化应激的改善记忆力活性肽及其制备方法，ZL202010755473.8
[7] 闵伟红；杨栋梁；宋文天；刘春雷；傅俊曦；曾琦；王钰盛，一种提高活性肽
ACE抑制率的修饰方法、ACE抑制肽及其应用，ZL202210192808.9
[8] 闵伟红；杨栋梁；宋文天；刘春雷；傅俊曦；曾琦；王钰盛，一种提高活性肽ACE抑制率的修饰方法、ACE抑制肽及其应用，ZL202210192808.9
[9] 闵伟红；党乔；杨栋梁；刘春雷，一种高抗氧化可穿透血脑屏障的改善记忆力
衍生肽及其应用，ZL202210253978.3
[10] 闵伟红；卢红妍；刘春雷；王辑；方丽，一种高活性改善记忆力衍生肽及其应
用，ZL202111159425.3
[11] 闵伟红；高云娜；方丽；韩彩静，高酶活天冬氨酸激酶突变体、工程菌及该突变体的制备方法，ZL201811305138.7
[12] 闵伟红；刘春雷；李鸿梅；方丽；王辑，一种降血压肽及其应用，ZL201610517707.9
[13] 闵伟红；刘春雷；方丽，一种加压协同复合酶法缩短玉米浸泡时间的方法，ZL201410169053.6
[14] Jingwei Bai, Zhijie Chen; Method for controlling speed of polypeptide passing through the nanopore, and application thereof, EP3955002B1
[15] 白净卫，杜娟娟，陈志杰；一种形成薄膜的方法和应用，ZL201811337111.6
[16] 白净卫，陈志杰；一 种 控 制 多 肽 穿 过 纳 米 孔 速 度 的 方 法 及 应 用，ZL201910580964.0
[17] 罗永挺，安鹏，罗俊杰，赵文婷，夏祎，朱林；T-5224在预防小鼠主动脉夹层疾病中的用途，ZL20221 1488902.5
3.科技成果奖
[1] 2019，国家科学技术进步奖二等奖
[2] 2015，农业部中华农业科技成果一等奖
[3] 2020，吉林省科技进步二等奖
[4] 2014，吉林省科技进步一等奖
[5] 2012，吉林省科技进步二等奖
[6] 2010，吉林省科技进步一等奖
4.学术论文
[1] Oral delivery systems for food-derived bioactive peptides: enhancing stability, bioavailability, and health benefits. Advanced science, 2026, 10.1002/advs.76666.
[2] Exploring the brain protective potential of nut protein peptides from a choline perspective: current advances and future trends. Trends in food science and technology. 2026, 172.
[3] Efficient preparation and decolorization of water-soluble walnut meal protein: Characterization of structure and function. Food Chemistry. 2026, 516:149397.
[4] Mechanisms of temperature-regulated flavor quality and lipid homeostasis in hickories storage process. LWT. 2026, 252:119601.
[5] Internalization and transport mechanisms of the walnut-derived peptide in bEnd.3 cells. Food science and human wellness. 2026, 15(2).
[6] Structural engineering of tyrosine-based neuroprotective peptides: a new strategy for efficient blood-brain barrier penetration. Foods. 2025, 14(21):3744.
[7] Hazelnut-derived peptide YYLLVR improves endothelial dysfunction in hypertension by activating ACE2. Journal of Agricultural and Food Chemistry, 2025, 73(27):17024-17039.
[8] Identification of walnut-derived peptide WNP-8 as a potential therapeutic agent and SIRT2 as a biomarker for cognitive deficiency: A label. International Journal of Biological Macromolecules. 2025, 286:138432.
[9] Enzymatic preparation of walnut-derived peptides and their neuroprotective effects in a mouse model of early Alzheimer's disease. Food Bioscience. 2025, 71:107214.
[10] Spike signals and MD simulations reveal the significance of peptide stretching in nanopore protein sequencing. Journal of the American Chemical Society, 2025, 147, 24347-24359.
[11] The endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis. Blood. 2025,146(14):1722-1736.
[12] Temporal-specific single cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targets. Science Bulletin. 2025, 70(2):167-171.
[13] Walnut peptide and ginseng Rg1 co-treatment prevents the loss of neurons and cognitive decline in mouse model with memory impairment. Food Science and Human Wellness. 2024, FSHW.2024.9250156.
[14] Novel strategy to the characterization and enhance the glycemic control properties of walnut-derived peptides via zinc chelation. Food Chemistry. 2024, 441:138288.
[15] Caveolin regulates the transport mechanism of the walnut-derived peptide EVSGPGYSPN to penetrate the blood-brain barrier. Journal of Agricultural and Food Chemistry. 2024, 72(36):19786-19799.
[16] Walnut-derived peptides cross the blood-brain barrier and ameliorate Aβ-induced hypersynchronous neural network activity. Food Research International. 2024, 197(Pt 2):115302.
[17] Interaction between the neuroprotective and hyperglycemia mitigation effects of walnut-derived peptide LVRL via the Wnt3a/β-Catenin/GSK-3β pathway in a type 2 diabetes mellitus model. Journal of Agricultural and Food Chemistry. 2024, 72(29):16204-16220.
[18] Walnut-derived peptides ameliorate scopolamine-induced memory impairments in a mouse model via activation of peroxisome proliferator-activated receptor γ-mediated excitotoxicity. Journal of Agricultural and Food Chemistry. 2024, 72(22):12541-12554.
[19] Effect of bi-enzyme hydrolysis on the properties and composition of hydrolysates of Manchurian walnut dreg protein. Food Chemistry. 2024, 447:138947.
[20] A combined in vitro and in silico study of the inhibitory mechanism of angiotensin-converting enzyme with peanut peptides. International Journal of Biological Macromolecules. 2024, 268(Pt 2):131901.
[21] Therapeutic effects of a walnut-derived peptide on NLRP3 inflammasome activation, synaptic plasticity, and cognitive dysfunction in T2DM mice. Food & Function, 2024, 15, 2295-2313.
[22] The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture. European Heart Journal. 2024, 45(4):287-305.
[23] Walnut-derived peptides promote autophagy via the activation of AMPK/mTOR/ULK1 pathway to ameliorate hyperglycemia in type 2 diabetic mice. Journal of Agricultural and Food Chemistry, 2023, 71(8), 3751-3765.
[24] Structure-activity relationship of walnut peptide in gastrointestinal digestion, absorption and antioxidant activity. LWT- Food Science and Technology, 2023, 189, 115521.
[25] Walnut-derived peptide improves cognitive impairment in colitis mice induced by dextran sodium sulfate via the microbiota-gut-brain axis (MGBA). Journal of Agricultural and Food Chemistry, 2023, 71(49), 19501–19515.
[26] Food-derived peptides: beneficial CNS effects and cross-BBB transmission Strategies. Journal of Agricultural and Food Chemistry. 2023, 71(51):20453-20478.
[27] Recent advances in the metabolic engineering and physiological opportunities for microbial synthesis of L-aspartic acid family amino acids: A review. International Journal of Biological Macromolecules. 2023, 253(Pt 3):126916.
[28] Mechanism of intestinal epithelial absorption and electrophysiological regulation of the shrimp peptide QMDDQ. Journal of Agricultural and Food Chemistry. 2023, 72(1):326-338.
[29] Structure-activity relationship of walnut peptide in gastrointestinal digestion, absorption and antioxidant activity. LWT. 2023, 189:115521.
[30] Anti-inflammatory effect of walnut-derived peptide via the activation of Nrf2/Keap1 pathway against oxidative stress. Journal of Functional Foods. 2023 Nov;110:105839.
[31] Neuroprotective mechanism of walnut-derived peptide via C1q-mediated synaptic plasticity in HT22 cells. Food Bioscience. 2023 Dec;56:103244.
[32] Effects of epigallocatechin-3-gallate on the structural hierarchy of the gluten network in dough. Food Hydrocolloids. 2023 Sep;142:108803.
[33] Complement in human brain health: potential of dietary food in relation to neurodegenerative diseases. Foods,2023, 12(19), 3580.
[34] Synergistic effect of combined walnut peptide and ginseng extracts on memory improvement in C57BL/6 mice and potential mechanism Exploration. Foods, 2023, 12, 2329.
[35] Characterization of aspartokinase double mutants using a combination of experiments and simulations. Heliyon, 2023, 9, 13133.
[36] Insights into the hippocampus proteomics reveal epigenetic properties of walnut-derived peptides in a low-grade neuroinflammation model. Food Research International, 2022, 156, 111311.
[37] Walnut-derived peptide enhances mitophagy via JNK-mediated PINK1 activation to reduce oxidative stress in HT-22 cells.Journal of Agricultural and Food Chemistry, 2022, 70(8): 2630-2642.
[38] Walnut-derived peptides ameliorate D-galactose-induced memory impairments in a mouse model via inhibition of MMP-9-mediated blood-brain barrier disruption. Food Research International, 2022, 162: 112029.
[39] Advances on the antioxidant peptides from nuts: a narrow review. Antioxidants, 2022, 11(10), 2020
[40] Walnut-derived peptide activates PINK1 via the NRF2/KEAP1/HO-1 pathway, promotes mitophagy, and alleviates learning and memory impairments in a mice model. Journal of Agricultural and Food Chemistry, 2021, 69(9): 2758-2772.
[41] Controlled movement of ssDNA conjugated peptide through Mycobacterium smegmatis porin A (MspA) nanopore by a helicase motor for peptide sequencing application. Chemical Science, 2021, 12, 15750.
[42] Neuroprotection by walnut-derived peptides through autophagy promotion via Akt/mTOR signaling pathway against oxidative stress in PC12 cells, Journal of Agricultural and Food Chemistry, 2020, 68, 11, 3638-3648.
[43] Peptides from walnut (Juglans mandshurica Maxim.) protect hepatic HepG2 cells from high glucose-induced insulin resistance and oxidative stress. Food & Function, 2020, 11(9), 8112-8121.
[44] Potential mechanisms mediating the protective effects of a peptide from walnut (Juglans mandshurica Maxim.) against hydrogen peroxide induced neurotoxicity in PC12 cells. Food & Function, 2019, 10, 63491-3501.
[45] Evaluation of the antidiabetic activity of hydrolyzed peptides derived from Juglans mandshurica Maxim. fruits in insulin-resistant HepG2 cells and type 2 diabetic mice.Food Biochemistry. 2018, 42, e12518.
[46] Antioxidant hydrolyzed peptides from Manchurian walnut (Juglans mandshurica Maxim.) attenuate scopolamine-induced memory impairment in mice. Journal of the Science of Food and Agriculture, 2018, 98(13), 5142-5152.
